Identification of boundary heat flux assuring the destruction of target region of biological tissue - application of generalized dual-phase lag model and gradient method
In the paper an axially symmetrical biological tissue domain subjected to an external heat source is analyzed. The thermal processes occurring in the domain considered are described using the generalized dual-phase lag model supplemented by the Neumann boundary conditions and the appropriate initial conditions. The problem of tissue heating is solved using the implicit scheme of the finite difference method. The obtained solution allows one to determine the local and temporary values of the Arrhenius integral. Next, the inverse problem related to the identification of the boundary heat flux assuring the postulated destruction of the tissue target region is considered. The problem is solved using the gradient method. In the final part of the paper the results of computations and the conclusions are presented.
KeywordsBioheat transfer, Generalized dual-phase lag model, Arrhenius integral, Inverse problem, Finite difference method, Gradient method,
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